On February 24, 2008, Seinfeld appeared as the voice of his Bee Movie animated character Barry, at the 80th Academy Awards as the presentor for "Best Animated Short". Before announcing the nominees, he showed a montage of film clips featuring bees, claiming that they were some of his early work (as Barry).

Amidst his spring 2008 tour Jerry Seinfeld will be making a stop in his hometown of New York City for a one-night-only performance on June 2, 2008 at the WaMu Theater at Madison Square Garden to benefit Stand Up for a Cure SUFAC, a charity aiding lung cancer research at Memorial Sloan-Kettering Cancer Center.

On March 7, 2008, the New York Post reported Seinfeld "may be ready to get back on network television and rip off his pal Larry David's idea with his whole "Curb Your Enthusiasm" story line." According to the report, "the series, which is aiming for a June (2008) premiere, will be set in New York and will feature Jerry Seinfeld playing himself in an exaggerated reality."